Yasuaki Shimizu Selected Research

CCR3 Receptors

6/2007	A dual antagonist for chemokine CCR3 receptor and histamine H1 receptor.
4/2006	A novel, selective, and orally available antagonist for CC chemokine receptor 3.
1/2006	In vitro and in vivo characterization of a novel CCR3 antagonist, YM-344031.

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Yasuaki Shimizu Research Topics

Disease

8	Asthma (Bronchial Asthma) 06/2013 - 01/2006
8	Inflammation (Inflammations) 06/2013 - 01/2006
5	Pain (Aches) 09/2014 - 09/2010
4	Arthritis (Polyarthritis) 09/2014 - 03/2007
4	Respiratory Hypersensitivity 06/2013 - 01/2008
4	Infections 08/2011 - 02/2005
3	Chronic Pain 07/2013 - 01/2010
3	Vomiting 01/2012 - 07/2006
3	Hypersensitivity (Allergy) 12/2008 - 01/2006
2	Fibromyalgia (Fibrositis) 07/2013 - 01/2012
2	Hyperalgesia 07/2013 - 09/2010
2	Myalgia 07/2013 - 01/2012
2	Chronic Obstructive Pulmonary Disease (COPD) 01/2012 - 05/2011
2	Eosinophilia 01/2012 - 08/2008
2	Osteoarthritis 01/2011 - 09/2010
2	Rheumatoid Arthritis 12/2008 - 03/2007
2	Atopic Dermatitis (Atopic Eczema) 06/2007 - 01/2006
1	Bone Resorption 06/2022
1	Osteoporosis 06/2022
1	Schizophrenia (Dementia Praecox) 07/2013
1	Central Nervous System Diseases (CNS Diseases) 07/2013
1	Obesity 07/2013
1	Pneumonia (Pneumonitis) 01/2012
1	Vascular System Injuries 01/2012
1	Neuralgia (Stump Neuralgia) 01/2012
1	Herpes Genitalis (Genital Herpes) 08/2011
1	Lung Injury 05/2011
1	Disease Progression 08/2010
1	Autoimmune Diseases (Autoimmune Disease) 12/2008
1	Graft vs Host Disease (Graft-Versus-Host Disease) 12/2008
1	Autoimmune Hepatitis 12/2008
1	Leukemia 01/2008
1	Allergic Rhinitis 06/2007
1	Experimental Arthritis 03/2007
1	Edema (Dropsy) 11/2006
1	Contact Dermatitis (Eczema, Contact) 11/2006

Drug/Important Bio-Agent (IBA)

6	Analgesics (Analgesic Drugs)IBA 09/2014 - 01/2010
6	Pharmaceutical PreparationsIBA 06/2013 - 02/2005
5	3- (4- (3- chlorophenyl)- 1- ethyl- 7- methyl- 2- oxo- 1,2- dihydro- 1,8- naphthyridin- 3- yl)propanoic acidIBA 01/2012 - 05/2011
4	AntigensIBA 06/2013 - 01/2008
4	RoflumilastIBA 01/2012 - 06/2011
4	Phosphodiesterase 4 InhibitorsIBA 01/2012 - 07/2006
3	Prednisolone (Predate)FDA LinkGeneric 06/2022 - 01/2008
3	CilomilastIBA 01/2012 - 06/2011
3	rho-Associated KinasesIBA 01/2011 - 01/2010
3	1- (2- hydroxy- 1- phenylethyl)- 3- (4- (pyridin- 4- yl)phenyl)ureaIBA 01/2011 - 01/2010
3	Cyclosporine (Ciclosporin)FDA LinkGeneric 12/2008 - 11/2006
3	CCR3 ReceptorsIBA 06/2007 - 01/2006
3	N- (4,6- dimethylpyrimidin- 2- yl)- 4- (2- (4- methoxy- 3- methylphenyl)- 5- (4- methylpiperazin- 1- yl)- 4,5,6,7- tetrahydro- 1H- indol- 1- yl)benzenesulfonamide difumarateIBA 03/2007 - 07/2006
2	Reserpine (Serpasil)FDA Link 07/2013 - 01/2012
2	OvalbuminIBA 01/2012 - 08/2008
2	Valacyclovir (Valtrex)FDA LinkGeneric 08/2011 - 08/2010
2	ASP2151IBA 08/2011 - 08/2010
2	DNA Primase (Primase)IBA 08/2011 - 08/2010
2	CytokinesIBA 12/2008 - 01/2008
2	4- methyl- 4'- (3,5- bis(trifluoromethyl)- 1H- pyrazol- 1- yl)- 1,2,3- thiadiazole- 5- carboxanilideIBA 12/2008 - 01/2008
2	LigandsIBA 09/2006 - 04/2006
1	tartaric acid (tartrate)FDA Link 06/2022
1	deoxypyridinolineIBA 06/2022
1	AcidsIBA 06/2022
1	SodiumIBA 09/2014
1	5-HT2C Serotonin ReceptorIBA 07/2013
1	vabicaserinIBA 07/2013
1	lorcaserinIBA 07/2013
1	YM348IBA 07/2013
1	ASP5642IBA 06/2013
1	Formyl Peptide Receptors (Formyl Peptide Receptor)IBA 06/2013
1	ramatrobanIBA 06/2013
1	Biogenic Amines (Biogenic Amine)IBA 01/2012
1	Dihydrotachysterol (AT 10)IBA 01/2012
1	LipopolysaccharidesIBA 01/2012
1	Mexiletine (Mexitil)FDA LinkGeneric 01/2012
1	Adrenergic Receptors (Adrenergic Receptor)IBA 01/2012
1	Therapeutic UsesIBA 08/2011
1	Acyclovir (Aciclovir)FDA LinkGeneric 08/2011
1	EmeticsIBA 06/2011
1	SmokeIBA 05/2011
1	BradykininIBA 01/2011
1	Proteins (Proteins, Gene)FDA Link 09/2010
1	Urea (Carbamide)FDA LinkGeneric 09/2010
1	Streptozocin (Streptozotocin)FDA Link 01/2010
1	2- ((4- morpholin- 4- ylphenyl)amino)- 4- ((2,3,6- trifluorobenzyl)amino)pyrimidine- 5- carboxamideIBA 08/2008
1	Immunoglobulin E (IgE)IBA 01/2008
1	LeukotrienesIBA 01/2008
1	N- (1- ((6- fluoro- 2- naphthyl)methyl)pyrrolidin- 3- yl)- 2- (1- ((6- methylpyridazin- 3- yl)carbonyl)piperidin- 4- ylidene)acetamideIBA 06/2007
1	Anti-Allergic Agents (Antiallergic Agents)IBA 06/2007
1	Histamine (Histamine Dihydrochloride)FDA Link 06/2007
1	Histamine H1 Receptors (Histamine H1 Receptor)IBA 06/2007
1	ChemokinesIBA 06/2007
1	Type 7 Cyclic Nucleotide PhosphodiesterasesIBA 03/2007
1	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 11/2006
1	ZymosanIBA 11/2006
1	CarrageenanIBA 11/2006
1	Chemokine CCL5IBA 09/2006

Therapy/Procedure

1	Oral Administration 06/2022
1	Intra-Articular Injections 09/2014
1	Therapeutics 07/2013
1	Drug Therapy (Chemotherapy) 01/2012
1	Aftercare (After-Treatment) 08/2011
1	Anesthesia 06/2011